The major categories are wetting theory, adsorption theory, diffusion theory, electrostatic theory, and fracture theory. Bioadhesive polymeric platforms for transmucosal drug. The force required to detach the mucoadhesive tablet from the mucosa was regarded as the bioadhesive strength, and it was measured in terms of weight in grams. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical definition and solubility, while the chemical synthesis of polysaccharides is challenging with few reported examples of synthetic carbohydrate. Hence, it is necessary to deepen the study of the polymers properties. Formulation and development of mucoadhesive dental gel shital nishant shende 1. Overview on buccal drug delivery systems pharmainfo.
Therefore prolonged release of the incorporated drug scope. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains poorly defined. Quantitative evaluation of mucoadhesive polymers to. Mucoadhesion may be defined as the process where polymers attach to biological substrate. Formulation and in vitro evaluation of mucoadhesive. Mucoadhesive polymers are used to immobilize a drug delivery device on a speci. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil. Mucoadhesive polymers in the treatment of dry x syndrome. This makes the buccal cavity more suitable for mucoadhesive drug delivery. Polyethylene oxide polyoxtm is the good alternative of hpmc for the matrix system and shows the good swelling and mucoadhesive property. Introduction opical application of drugs to the eye is the most popular and wellaccepted route of administration for the treatment of various eye disorders.
Nine tablet formulations were prepared containing various mucoadhesive polymers. In addition to factors related to the oral mucosa and oral environment features, the physicalchemical characteristics of mucoadhesive polymers must be also considered as factors influencing the. Three main parameters for evaluating the polymers in nasal drug. Dumore1 1dadasaheb balpande college of diploma in pharmacy, besa nagpur 2gurunanak college of pharmacy, nagpur need for injection would be a major advance in dental pain control, this research work was planned with there. Mucoadhesive polymers for oral transmucosal drug delivery. The application of mucoadhesive polymers in nasal drug delivery systems has gained to promote dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage forms contact time and residence time with the mucous membranes. The present research mainly focuses on the screening of different mucoadhesive polymers for the development of mucoadhesive tablets with intestinal target. Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. The mucoadhesive polymers play the key role in determining the mucoadhesive ability of a dosage form. Evaluation of the mucosal retention properties and. Pdf mucoadhesive polymers for enhancing retention in. Formulation and evaluation of mucoadhesive bilayer buccal tablets of labetalol hydrochloride using natural polymers ar.
Mucoadhesion, polymers, evaluation parameters introduction the termmucoadhesion bioadhesionis used to describe adhesion interactions between polymers and mucus or mucosal surfaces suresh et al. Mucoadhesive polymers for enhancing retention in ocular drug delivery. Polyoxtm n 80 is one of the moderate viscosity grades while polyoxtm wsr 303 is highest viscosity grade. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will. The various new technology uses in development of nasal drug delivery dosage forms are discussed. Design of mucoadhesive plga microparticles for ocular drug. Here, we provide an overview of different mucoadhesive polymers with a focus on the relevance for the treatment of dry x syndrome. The mucoadhesive buccal films of ranitidine were prepared by solvent casting technique using polymers like hydroxy propyl methyl cellulose15 cps and poly vinyl pyrrolidone. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod. Adhesion of a matter to this layer is hence called mucoadhesion.
A focus on mucoadhesive polymers and their application in. The mucoadhesive drug delivery system includes the following. Xray diffraction study xrd the crystallinities of nevirapine and. Assessment of the mucoadhesive properties of mucolox using a 3d model of the human oral mucosa evaluation of the safety and toxicological profile of mucolox. Development and evaluation of mucoadhesive buccal tablets.
In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. Formulation and development of mucoadhesive dental gel. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug. Mdds utilizes the property of bioahesion of certain watersoluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic. Bioadhesive and mucoadhesive polymers authorstream presentation. Mucoadhesive polymers are versatile not only in their mechanisms of attachment, but also their origin. Formulation and evaluation of nevirapine mucoadhesive.
Volume 39, issue 12, december 2014, pages 20302075. Feasibility investigation of cellulose polymers for. Mucoadhesive polymers have recently gained interest among p harmaceutical scientists as a means of improving drug deliv ery by promotin g dosage from residence time and contact time with the. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application. Polymers with thiol groups might represent a new generation of mucoadhesive polymers displaying comparatively stronger adhesive properties. Tablets were prepared by direct compression and evaluated for mucoadhesive strength and invitro dissolution parameters. Mucoadhesive tablets from each batch, under a constant weight of 5 g, were then placed onto the mucosal membrane for 1 minute. Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries.
Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. It has been widely used for developing drug delivery systems because of its excellent mucoadhesive properties. The feasibility of various cellulose polymer derivatives, including methylcellulose mc, hydroxypropyl methylcellulose hpmc, sodiumcarboxymethylcellulose sodiumcmc, and cationichydroxyethylcellulose cationichec, for use as an excipient to enhance drug delivery in nasal spray formulations was investigated. Mucoadhesive polymers mucoadhesive polymers are either water soluble or insoluble, derived from natural or synthetic source and are able to form several hydrogen bonds because of the presence of carboxyl or hydroxyl functional groups. The bioavailability of ophthalmic drugs is, however, very poor due to efficient protective mechanisms of the eye. Mucoadhesive polymers in the design of nanodrug delivery. Aiswarya and mohd azharuddin department of pharmaceutics, srinivas college of pharmacy, valachil, mangalore, karnataka, india. The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. Formulation and evaluation of mucoadhesive bilayer buccal.
The compatibility of kt with various excipients was determined by ftir. Human oral mucosa, nasal mucosa and vaginal mucosa part evaluation of the safety and toxicological profile of mucolox. Design and in vivo evaluation of buccoadhesive hydrophilic. Since the early 1980,the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. Samples 5mg each were accurately weighed into aluminum pans and sealed. Buccal mucoadhesive drug delivery system pdf used for the preparation of mucoadhesive buccal patches. First generation mucoadhesive polymers anionic polymers polyacrylic acids carbomers, sodium alginate cationic polymers chitosan nonionic polymers cellulose derivatives hydroxyl, carboxyl or amine groups on the molecules favours adhesion formulation challenges due to hydrophilicity and limited solubility in other solvents. All the ingredients including drug, polymer and other tablet excipients. Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. Mucoadhesive polymers are able to interact with mucus which is secreted by the underlying tissue.
It is proposed that the hydrogen bondforming capacity of the polymer is important in this effect, and may emphasize the welldocumented mucoadhesive properties of polymers possessing numerous carboxyl groups such as carbopol and polycarbophil. In design and develop mdds are discussed with special emphasis on the mechanism. So far, a considerable number of studies focusing on the mucoadhesive. Mucoadhesive polymers have been developed for buccal, nasal, ocular, vaginal and oral applications. A more specific term than bioadhesion is mucoadhesion. Specific processes include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption.
Mucoadhesive drug delivery system linkedin slideshare. Mucoadhesive drug delivery system is a part of controlled delivery system. Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting dosage from residence time and contact time with the mucous membranes. Mucoadhesive polymers like carbopol 934p,sodium cmc and sodium alginate were used in. Mucoadhesive polymers in the design of nanodrug delivery systems for administration by nonparenteral routes.
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